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23 February 2010 Robotically assisted small animal MRI-guided mouse biopsy
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Abstract
Small mammals, namely mice and rats, play an important role in biomedical research. Imaging, in conjunction with accurate therapeutic agent delivery, has tremendous value in small animal research since it enables serial, non-destructive testing of animals and facilitates the study of biomarkers of disease progression. The small size of organs in mice lends some difficulty to accurate biopsies and therapeutic agent delivery. Image guidance with the use of robotic devices should enable more accurate and repeatable targeting for biopsies and delivery of therapeutic agents, as well as the ability to acquire tissue from a pre-specified location based on image anatomy. This paper presents our work in integrating a robotic needle guide device, specialized stereotaxic mouse holder, and magnetic resonance imaging, with a long-term goal of performing accurate and repeatable targeting in anesthetized mice studies.
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Emmanuel Wilson, Chris Chiodo, Kenneth H. Wong, Stanley Fricke, Mira Jung, and Kevin Cleary "Robotically assisted small animal MRI-guided mouse biopsy", Proc. SPIE 7625, Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling, 762520 (23 February 2010); https://doi.org/10.1117/12.845566
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