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23 February 2010MRI-GUIDED prostate motion tracking by means of multislice-to-volume
registration
We developed an algorithm for tracking prostate motion during MRI-guided prostatic needle placement, with the
primary application in prostate biopsy. Our algorithm has been tested on simulated patient and phantom data. The
algorithm features a robust automatic restart and a 12-core biopsy error validation scheme. Simulation tests were
performed on four patient MRI pre-operative volumes. Three orthogonal slices were extracted from the pre-operative
volume to simulate the intra-operative volume and a volume of interest was defined to isolate the prostate. Phantom tests
used six datasets, each representing the phantom at a known perturbed position. These volumes were registered to their
corresponding reference volume (the phantom at its home position). Convergence tests on the phantom data showed that
the algorithm demonstrated accurate results at 100% confidence level for initial misalignments of less than 5mm and at
73% confidence level for initial misalignments less than 10mm. Our algorithm converged in 95% of the cases for the
simulated patient data with 0.66mm error and the six phantom registration tests resulted in 1.64mm error.
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Hadi Tadayyon, Siddharth Vikal, Sean Gill, Andras Lasso, Gabor Fichtinger, "MRI-GUIDED prostate motion tracking by means of multislice-to-volume registration," Proc. SPIE 7625, Medical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling, 76252V (23 February 2010); https://doi.org/10.1117/12.844454