Near-infrared autofluorescence imaging for colonic cancer detection

Xiaozhuo Shao; Wei Zheng; Zhiwei Huang

doi:10.1117/12.852098

25 November 2009 Near-infrared autofluorescence imaging for colonic cancer detection

Xiaozhuo Shao, Wei Zheng, Zhiwei Huang

Proceedings Volume 7634, Optical Sensors and Biophotonics; 76340B (2009) https://doi.org/10.1117/12.852098
Event: Asia Communications and Photonics, 2009, Shanghai, Shanghai , China

Abstract

We explore an NIR autofluorescence imaging technique for cancer diagnosis and detection. A set of tissue images including NIR white light images, autofluorescence (AF) images and fluorescence polarized images (FPI) (parallel-, and perpendicular- polarization) were acquired in tandem on human colonic tissues. The results show that NIR fluorescence intensity of normal tissue is significantly higher than that of cancer tissue. The perpendicular-polarization image yields the highest diagnostic accuracy 93% compared to other imaging modes. This work demonstrates that Fluorescence polarization imaging (FPI) technique has great potential for cancer diagnosis and detection in the colon.

Citation Download Citation

Xiaozhuo Shao, Wei Zheng, and Zhiwei Huang "Near-infrared autofluorescence imaging for colonic cancer detection", Proc. SPIE 7634, Optical Sensors and Biophotonics, 76340B (25 November 2009); https://doi.org/10.1117/12.852098

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