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23 April 2010 Gadolinium-labeled dendronized gold nanoparticles as new targeted MRI contrast agent
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Abstract
Early diagnosis is critical for positive outcome of cancer treatments. In many cases, lives would be saved if the tumor could be detected at a very early stage. Nanoparticles have the property of passively targeting tumor sites due to their enhanced permeation and retention (EPR) effect. Thus they can play a critical role in improving the ability to find cancer in its earliest and most treatable stages. Furthermore magnetic resonance imaging is one of the most precise techniques for cancer screening since it can show 3D images of the tumors. For a better enhancement of the sensitivity of this method, MRI contrast agent (DOTA)Gd was attached to poly(propylene imine) dendrons of third generation and the obtained dendrons were used for modification of gold nanoparticles.
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Hongmu Pan and Marie-Christine Daniel "Gadolinium-labeled dendronized gold nanoparticles as new targeted MRI contrast agent", Proc. SPIE 7674, Smart Biomedical and Physiological Sensor Technologies VII, 767404 (23 April 2010); https://doi.org/10.1117/12.850175
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