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23 April 2010 Chemically responsive hydrogel with nanoparticle enhanced detection for small biomolecules
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A surface plasmon resonance (SPR) sensor to quantify glucose using a molecularly imprinted polymer was developed. The polymer was prepared by crosslinking poly(allylamine) in the presence of glucose phosphate, monobarium salt (GPS-Ba) and attached to a thin film of gold (50 nm) which had been sputtered on top of a glass slide, via amide coupling. Upon removal of the template, this sensor was used to detect glucose in human urine in physiologically significant levels (1-20 mg/ml). Signal enhancement of the glucose sensor was made possible by incorporating gold nanoparticles in the polymer.
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Soame Banerji, Wei Peng, Yoon-Chang Kim, and Karl S. Booksh "Chemically responsive hydrogel with nanoparticle enhanced detection for small biomolecules", Proc. SPIE 7674, Smart Biomedical and Physiological Sensor Technologies VII, 76740A (23 April 2010);

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