Chemically responsive hydrogel with nanoparticle enhanced detection for small biomolecules

Soame Banerji; Wei Peng; Yoon-Chang Kim; Karl S. Booksh

doi:10.1117/12.854610

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23 April 2010 Chemically responsive hydrogel with nanoparticle enhanced detection for small biomolecules

Soame Banerji, Wei Peng, Yoon-Chang Kim, Karl S. Booksh

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Proceedings Volume 7674, Smart Biomedical and Physiological Sensor Technologies VII; 76740A (2010) https://doi.org/10.1117/12.854610
Event: SPIE Defense, Security, and Sensing, 2010, Orlando, Florida, United States

Abstract

A surface plasmon resonance (SPR) sensor to quantify glucose using a molecularly imprinted polymer was developed. The polymer was prepared by crosslinking poly(allylamine) in the presence of glucose phosphate, monobarium salt (GPS-Ba) and attached to a thin film of gold (50 nm) which had been sputtered on top of a glass slide, via amide coupling. Upon removal of the template, this sensor was used to detect glucose in human urine in physiologically significant levels (1-20 mg/ml). Signal enhancement of the glucose sensor was made possible by incorporating gold nanoparticles in the polymer.

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Soame Banerji, Wei Peng, Yoon-Chang Kim, and Karl S. Booksh "Chemically responsive hydrogel with nanoparticle enhanced detection for small biomolecules", Proc. SPIE 7674, Smart Biomedical and Physiological Sensor Technologies VII, 76740A (23 April 2010); https://doi.org/10.1117/12.854610

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