Photothermolysis of tumor with gold nanoparticles guided by NIR and acoustic thermometries

Marina A. Sirotkina; Marina V. Shirmanova; Marina L. Bugrova; Ludmila B. Snopova; Vadim V. Elagin; Pavel V. Subochev; Vladislav A. Kamensky; Anatoly D. Mansfel'd; Victor A. Nadtochenko; Elena V. Zagainova

doi:10.1117/12.854353

17 May 2010 Photothermolysis of tumor with gold nanoparticles guided by NIR and acoustic thermometries

Marina A. Sirotkina, Marina V. Shirmanova, Marina L. Bugrova, Ludmila B. Snopova, Vadim V. Elagin, Pavel V. Subochev, Vladislav A. Kamensky, Anatoly D. Mansfel'd, Victor A. Nadtochenko, Elena V. Zagainova

Author Affiliations +

Proceedings Volume 7715, Biophotonics: Photonic Solutions for Better Health Care II; 77150R (2010) https://doi.org/10.1117/12.854353
Event: SPIE Photonics Europe, 2010, Brussels, Belgium

Abstract

In the current paper we present preliminary data demonstrating therapeutic efficiency of local laser hyperthermia of mouse tumors with gold nanoparticles. Measuring the tumor temperatures both superficial and inner by means of standard NIR-thermograph and original acoustic thermometer correspondingly we show that the gold nanoparticles increase thermal sensitivity of tumor tissue. Transmission electron microscopy and histopathology of the tumor tissue indicated that the mechanism of apoptotic death of tumor cells is triggered following the laser treatment. 5 days after the treatment tumor growth inhibition was 104 %.

Citation Download Citation

Marina A. Sirotkina, Marina V. Shirmanova, Marina L. Bugrova, Ludmila B. Snopova, Vadim V. Elagin, Pavel V. Subochev, Vladislav A. Kamensky, Anatoly D. Mansfel'd, Victor A. Nadtochenko, and Elena V. Zagainova "Photothermolysis of tumor with gold nanoparticles guided by NIR and acoustic thermometries", Proc. SPIE 7715, Biophotonics: Photonic Solutions for Better Health Care II, 77150R (17 May 2010); https://doi.org/10.1117/12.854353

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