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8 November 2010 Monitoring collagen remodeling on opto-thermal response of photoaged skin irradiated by Er:YAG laser with optical coherence tomography
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Abstract
The Optical Coherence Tomography technology was used to perform noninvasive cross-sectional imaging of internal structures in photoaged mouse skin irradiated by Er:YAG laser. The mice were irradiated chronically with a steady dose of ultraviolet irradiation. Various laser light doses were irradiated on the back skins of the photoaged mouse. An OCT was used to observe the process of the collagen remodeling in dermis. The relationship between optical characteristic parameter such as attenuation coefficient and light dose was discovered. The total attenuation coefficient increased when the light dose increased. Our findings showed that Er:YAG laser could be used for the symptoms of the photoaged skin with some degree of thermal damage in the dermis, and the OCT could image the progress of collagen remodeling in photoaged mouse dermis. The OCT may be a useful tool for the determination of optimal parameters for laser skin treatment.
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Xiaoman Zhang, Shulian Wu, and Hui Li "Monitoring collagen remodeling on opto-thermal response of photoaged skin irradiated by Er:YAG laser with optical coherence tomography", Proc. SPIE 7845, Optics in Health Care and Biomedical Optics IV, 78450F (8 November 2010); https://doi.org/10.1117/12.868894
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