Uniform mesoporous dye-doped silica nanoparticles as a multifunctional drug carrier for in vivo early tumor diagnosis

Jie Cao; Junfei Xia; Dawei Deng; Yueqing Gu

doi:10.1117/12.866940

8 November 2010 Uniform mesoporous dye-doped silica nanoparticles as a multifunctional drug carrier for in vivo early tumor diagnosis

Jie Cao, Junfei Xia, Dawei Deng, Yueqing Gu

Author Affiliations +

Proceedings Volume 7845, Optics in Health Care and Biomedical Optics IV; 78451R (2010) https://doi.org/10.1117/12.866940
Event: Photonics Asia 2010, 2010, Beijing, China

Abstract

In this report, we synthesized multifunctional dye-doped mesoporous silica nanoparticles(MSNs) by encapsulating near-infrared dyes into the nanoparticles. In order to enhance the targeting property, the surface was modified with amino group for further conjugation of targeted ligands. In addition, we explored the influence of the synthetic temperature on the particle morphology. The optical properties, morphology and structure of the as-prepared dye-doped silica nanoparticles were characterized. Results indicated the dye-doped silica nanoparticles can be used as a good probe for early tumor diagnosis and have the potential to serve as a targeted carrier for antitumor drugs.

Citation Download Citation

Jie Cao, Junfei Xia, Dawei Deng, and Yueqing Gu "Uniform mesoporous dye-doped silica nanoparticles as a multifunctional drug carrier for in vivo early tumor diagnosis", Proc. SPIE 7845, Optics in Health Care and Biomedical Optics IV, 78451R (8 November 2010); https://doi.org/10.1117/12.866940

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