Fluorescence-guided surgical resection of oral cancer reduces recurrence

Pierre Lane; Catherine F. Poh; J. Scott Durham; Lewei Zhang; Sylvia F. Lam; Miriam Rosin; Calum MacAulay

doi:10.1117/12.876062

17 February 2011 Fluorescence-guided surgical resection of oral cancer reduces recurrence

Pierre Lane, Catherine F. Poh, J. Scott Durham, Lewei Zhang, Sylvia F. Lam, Miriam Rosin, Calum MacAulay

Proceedings Volume 7883, Photonic Therapeutics and Diagnostics VII; 78832X (2011) https://doi.org/10.1117/12.876062
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Approximately 36,000 people in the US will be newly diagnosed with oral cancer in 2010 and it will cause 8,000 new deaths. The death rate is unacceptably high because oral cancer is usually discovered late in its development and is often difficult to treat or remove completely. Data collected over the last 5 years at the BC Cancer Agency suggest that the surgical resection of oral lesions guided by the visualization of the alteration of endogenous tissue fluorescence can dramatically reduce the rate of cancer recurrence. Four years into a study which compares conventional versus fluorescence-guided surgical resection, we reported a recurrence rate of 25% (7 of 28 patients) for the control group compared to a recurrence rate of 0% (none of the 32 patients) for the fluorescence-guided group. Here we present resent results from this ongoing study in which patients undergo either conventional surgical resection of oral cancer under white light illumination or using tools that enable the visualization of naturally occurring tissue fluorescence.

Citation Download Citation

Pierre Lane, Catherine F. Poh, J. Scott Durham, Lewei Zhang, Sylvia F. Lam, Miriam Rosin, and Calum MacAulay "Fluorescence-guided surgical resection of oral cancer reduces recurrence", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78832X (17 February 2011); https://doi.org/10.1117/12.876062

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