Image-guided photoacoustic spectroscopy in diagnosis of osteoarthritis in hands: an initial study

Zhen Yuan; J. Xiao; Yao Sun; Eric S. Sobel; Jishan He; Huabei Jiang

doi:10.1117/12.879439

18 February 2011 Image-guided photoacoustic spectroscopy in diagnosis of osteoarthritis in hands: an initial study

Zhen Yuan, J. Xiao, Yao Sun, Eric S. Sobel, Jishan He, Huabei Jiang

Proceedings Volume 7883, Photonic Therapeutics and Diagnostics VII; 78834N (2011) https://doi.org/10.1117/12.879439
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

We present for the first time in vivo experimental evidence that multispectral quantitative photoacoustic tomography (qPAT) has the potential to detect osteoarthritis (OA) in the finger joints. In this pilot study, 2 OA patients and 4 healthy volunteers were enrolled, and their distal interphalangeal (DIP) joints were examined photoacoustically by a multispectral PAT scanner. Images of tissue physiological/functional parameters including oxy-hemoglobin, deoxyhemoglobin, oxygen saturation and water content along with tissue acoustic velocity of all the examined joints were simultaneously recovered using a finite element reconstruction algorithm for multispectral photoacoustic measurements. The recovered multispectral photoacoustic images show that the OA joints have significantly elevated water content, decreased oxygen saturation, and increased acoustic velocity compared to the normal joints.

Citation Download Citation

Zhen Yuan, J. Xiao, Yao Sun, Eric S. Sobel, Jishan He, and Huabei Jiang "Image-guided photoacoustic spectroscopy in diagnosis of osteoarthritis in hands: an initial study", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 78834N (18 February 2011); https://doi.org/10.1117/12.879439

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