Millimeter wave-induced changes in membrane properties of leech Retzius neurons

Victor Pikov; Peter H. Siegel

doi:10.1117/12.875758

18 February 2011 Millimeter wave-induced changes in membrane properties of leech Retzius neurons

Victor Pikov, Peter H. Siegel

Proceedings Volume 7883, Photonic Therapeutics and Diagnostics VII; 788356 (2011) https://doi.org/10.1117/12.875758
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

This study evaluated a novel method for modulation of neuronal excitability using non-invasive delivery of millimeter waves. Millimeter waves at 60 GHz and incident power density of 100-600 μW/cm² were applied to three intact segmental ganglia of the adult leach, and intracellular neuronal activity was recorded from the Retzius neurons using intracellular glass electrode. Transient dosedependent increase in the plasma membrane permeability was observed. In addition, in one of the examined neurons, a decrease in the neuronal firing rate was also evident. The results provide strong evidence for the feasibility of modulating neuronal excitability using non-invasive delivery of millimeter waves, and will be explored further for applications in basic neuroscience and treatment of neurological disorders.

Citation Download Citation

Victor Pikov and Peter H. Siegel "Millimeter wave-induced changes in membrane properties of leech Retzius neurons", Proc. SPIE 7883, Photonic Therapeutics and Diagnostics VII, 788356 (18 February 2011); https://doi.org/10.1117/12.875758

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