Determining how uncertainties in optical properties affect light dose calculations for PDT

Julia Sandell; Jarod C. Finlay; Timothy C. Zhu

doi:10.1117/12.875378

10 February 2011 Determining how uncertainties in optical properties affect light dose calculations for PDT

Julia Sandell, Jarod C. Finlay, Timothy C. Zhu

Proceedings Volume 7886, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX; 78860N (2011) https://doi.org/10.1117/12.875378
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

The effectiveness of photodynamic treatment depends on several factors including an accurate knowledge of optical properties of the tissue to be treated. In order to correctly determine the needed light dose, the values of tissue optical properties must be well known. In this study we consider how the uncertainties in the measured values of optical properties affect the uncertainty in light dosimetry. By using phantoms with known optical properties we determine the uncertainties for several algorithms currently in the literature. We calculate the light fluence uncertainties using a finite element model solution to the diffusion equation in a cavity geometry. Using these uncertainties we conduct a statistical analysis, building a three dimensional space of uncertainties in μ_a, μ_s', and light dose. By characterizing this space we gain an understanding of the trend in uncertainties and determine which algorithms provide the most accurate light dose.

Citation Download Citation

Julia Sandell, Jarod C. Finlay, and Timothy C. Zhu "Determining how uncertainties in optical properties affect light dose calculations for PDT", Proc. SPIE 7886, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX, 78860N (10 February 2011); https://doi.org/10.1117/12.875378

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