EtNBS and EtNBS-COOH PDT efficacy in ovarian cancer cells

Yong Jin Park; Oliver J. Klein; Brijesh Bahayana; Conor L. Evans

doi:10.1117/12.877591

28 February 2011 EtNBS and EtNBS-COOH PDT efficacy in ovarian cancer cells

Yong Jin Park, Oliver J. Klein, Brijesh Bahayana, Conor L. Evans

Proceedings Volume 7886, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX; 78860W (2011) https://doi.org/10.1117/12.877591
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

The effective treatment of metastatic cancer continues to be a challenge due to the highly invasive nature of metastatic lesions and their propensity to develop therapeutic resistance. Optimal therapeutic regimens for peritoneal metastases should have both rapid uptake and penetrate throughout cancerous lesions. Using in vitro models of ovarian cancer, we have found that the cores of tumor nodules are both hypoxic and acidic, rendering most chemotherapeutic agents ineffective, and considerably reducing the therapeutic efficacy of the majority of photodynamic therapy (PDT) and radiation therapy regimens. PDT using EtNBS, a cationic photosensitizer, is a promising approach for treating these hypoxic and acidic nodule cores as it rapidly accumulates into the hypoxic cores of tumor nodules, and is effective even in completely anoxic environments. To improve the uptake rate of EtNBS into cells, we utilized a carboxylic acid terminated derivative of EtNBS that is zwitterionic at biological pH levels. In this study, we investigated the effect of this structural change on PDT efficacy in ovarian cancer cells.

Citation Download Citation

Yong Jin Park, Oliver J. Klein, Brijesh Bahayana, and Conor L. Evans "EtNBS and EtNBS-COOH PDT efficacy in ovarian cancer cells", Proc. SPIE 7886, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XX, 78860W (28 February 2011); https://doi.org/10.1117/12.877591

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