Silicon photonic microring resonator arrays for scalable and multiplexable bioanalysis

Matthew S. Luchansky; Adam L. Washburn; Abraham J. Qavi; Jared T. Kindt; Melinda S. McClellan; Ryan C. Bailey

doi:10.1117/12.880492

8 February 2011 Silicon photonic microring resonator arrays for scalable and multiplexable bioanalysis

Matthew S. Luchansky, Adam L. Washburn, Abraham J. Qavi, Jared T. Kindt, Melinda S. McClellan, Ryan C. Bailey

Proceedings Volume 7888, Frontiers in Biological Detection: From Nanosensors to Systems III; 788802 (2011) https://doi.org/10.1117/12.880492
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Silicon photonic devices, such as SOI microring resonators, have optical properties that are incredibly responsive to changes in the local dielectric environment accompanying a biological binding event at or near the ring surface. We have developed a platform in which arrays of uniquely addressable microrings are functionalized with target-specific capture agents so as to create a powerful tool for multiplexed biomolecular detection. We will discuss applications of this technology to the multiplexed detection of DNA, RNA, and proteins in clinically-relevant matrices, and will also describe the rigorous empirical determination of key sensitivity metrics.

Citation Download Citation

Matthew S. Luchansky, Adam L. Washburn, Abraham J. Qavi, Jared T. Kindt, Melinda S. McClellan, and Ryan C. Bailey "Silicon photonic microring resonator arrays for scalable and multiplexable bioanalysis", Proc. SPIE 7888, Frontiers in Biological Detection: From Nanosensors to Systems III, 788802 (8 February 2011); https://doi.org/10.1117/12.880492

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