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8 February 2011 Application of ring down measurement approach to micro-cavities for bio-sensing applications
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Abstract
Optical biosensors can detect biomarkers in the blood serum caused by either infections or exposure to toxins. Until now, most work on the micro-cavity biosensors has been based on measurement of the resonant frequency shift induced by binding of biomarkers to a cavity. However, frequency domain measurements are not precise for such high Q micro-cavities. We hypothesize that more accurate measurements and better noise tolerance can be achieved by the application of the ring down measurement approach to the micro-cavity in a biosensor. To test our hypothesis, we have developed a full vectorial finite element model of a silica toroidal micro-cavity immersed in water. Our modeling results show that a toroidal cavity with a major diameter of 70μm and a minor diameter of 6μm can achieve a sensitivity of 28.6μs/RIU refractive index units (RIU) at 580nm. Therefore, our sensor would achieve the resolution of 5 x 10-8 RIU by employing a detector with picosecond resolution. Hence we propose a micro-cavity ring down biosensor with high sensitivity which will find wide applications in real time and label free bio-sensing.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
M. Imran Cheema and Andrew G. Kirk "Application of ring down measurement approach to micro-cavities for bio-sensing applications", Proc. SPIE 7888, Frontiers in Biological Detection: From Nanosensors to Systems III, 788808 (8 February 2011); https://doi.org/10.1117/12.874890
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