Three dimensional time reversal optical tomography

Binlin Wu; W. Cai; M. Alrubaiee; M. Xu; S. K. Gayen

doi:10.1117/12.875982

10 February 2011 Three dimensional time reversal optical tomography

Binlin Wu, W. Cai, M. Alrubaiee, M. Xu, S. K. Gayen

Proceedings Volume 7892, Multimodal Biomedical Imaging VI; 78920G (2011) https://doi.org/10.1117/12.875982
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Time reversal optical tomography (TROT) approach is used to detect and locate absorptive targets embedded in a highly scattering turbid medium to assess its potential in breast cancer detection. TROT experimental arrangement uses multi-source probing and multi-detector signal acquisition and Multiple-Signal-Classification (MUSIC) algorithm for target location retrieval. Light transport from multiple sources through the intervening medium with embedded targets to the detectors is represented by a response matrix constructed using experimental data. A TR matrix is formed by multiplying the response matrix by its transpose. The eigenvectors with leading non-zero eigenvalues of the TR matrix correspond to embedded objects. The approach was used to: (a) obtain the location and spatial resolution of an absorptive target as a function of its axial position between the source and detector planes; and (b) study variation in spatial resolution of two targets at the same axial position but different lateral positions. The target(s) were glass sphere(s) of diameter ~9 mm filled with ink (absorber) embedded in a 60 mm-thick slab of Intralipid-20% suspension in water with an absorption coefficient μ_a ~ 0.003 mm^-1 and a transport mean free path l_t ~ 1 mm at 790 nm, which emulate the average values of those parameters for human breast tissue. The spatial resolution and accuracy of target location depended on axial position, and target contrast relative to the background. Both the targets could be resolved and located even when they were only 4-mm apart. The TROT approach is fast, accurate, and has the potential to be useful in breast cancer detection and localization.

Citation Download Citation

Binlin Wu, W. Cai, M. Alrubaiee, M. Xu, and S. K. Gayen "Three dimensional time reversal optical tomography", Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920G (10 February 2011); https://doi.org/10.1117/12.875982

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available