Potentialities of a new bimodal Xray/fluorescence tomograph within a cyindrical geometry for pre-clinical studies

Anne Koenig; Anne Planat-Chrétien; Jean-Guillaume Coutard; Lionel Hervé; Marco Brambilla; Véronique Josserand; Jean-Luc Coll; Jean-Marc Dinten

doi:10.1117/12.874453

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10 February 2011 Potentialities of a new bimodal Xray/fluorescence tomograph within a cylindrical geometry for pre-clinical studies

Anne Koenig, Anne Planat-Chrétien, Jean-Guillaume Coutard, Lionel Hervé, Marco Brambilla, Véronique Josserand, Jean-Luc Coll, Jean-Marc Dinten

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Proceedings Volume 7892, Multimodal Biomedical Imaging VI; 78920J (2011) https://doi.org/10.1117/12.874453
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

An instrument dedicated to the co-registration of optical and X-ray measurements is presented: specific acquisition protocol and reconstruction software have been developed for carrying out fluorescence diffuse optical tomography in a cylindrical geometry consistent with XCT. Actual animal geometry provided by the X-ray tomography is used to give animal boundaries to the diffuse optical tomography reconstruction algorithm. To evaluate performances of this new optical imaging system, experiments have been conducted on phantoms, mice with fluorescent capillaries, and finally on mice bearing tumors. The fluorescence reconstructions are shown to be geometrically consistent with X-ray ones. We determined that the sensibility limit of the system to detect fluorescence signal over intrinsic ones is 2 pmol for lungs area and 5 pmol for the abdomen area.

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Anne Koenig, Anne Planat-Chrétien, Jean-Guillaume Coutard, Lionel Hervé, Marco Brambilla, Véronique Josserand, Jean-Luc Coll, and Jean-Marc Dinten "Potentialities of a new bimodal Xray/fluorescence tomograph within a cylindrical geometry for pre-clinical studies", Proc. SPIE 7892, Multimodal Biomedical Imaging VI, 78920J (10 February 2011); https://doi.org/10.1117/12.874453

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