Translating ultraviolet autofluorescence microscopy toward clinical endomicroscopy

Bevin Lin; Shiro Urayama; Ramez M. G. Saroufeem; Dennis L. Matthews; Stavros G. Demos

doi:10.1117/12.871718

16 February 2011 Translating ultraviolet autofluorescence microscopy toward clinical endomicroscopy

Bevin Lin, Shiro Urayama, Ramez M. G. Saroufeem, Dennis L. Matthews, Stavros G. Demos

Proceedings Volume 7895, Optical Biopsy IX; 789502 (2011) https://doi.org/10.1117/12.871718
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

The potential of autofluorescence microscopy under ultraviolet excitation is investigated as a method to visualize superficial epithelial microstructures and their modification with progression of disease. This method does not require the use of contrast agents, sectioning methods, or tissue preparation. Imaging of esophagus tissue is the focus of this study and deals with three main issues: a) What is the origin of the signal; b) How the gradual microstructure modification associated with various stages of esophageal disease is visualized; c) What are the designing parameters for in vivo implementation.

Citation Download Citation

Bevin Lin, Shiro Urayama, Ramez M. G. Saroufeem, Dennis L. Matthews, and Stavros G. Demos "Translating ultraviolet autofluorescence microscopy toward clinical endomicroscopy", Proc. SPIE 7895, Optical Biopsy IX, 789502 (16 February 2011); https://doi.org/10.1117/12.871718

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