Prostate precancer detection by Stokes Shift Spectroscopy

Ebenezar Jeyasingh; Y. Pu; W. B. Wang; C. H. Liu; R. R. Alfano

doi:10.1117/12.876780

16 February 2011 Prostate precancer detection by Stokes Shift Spectroscopy

Ebenezar Jeyasingh, Y. Pu, W. B. Wang, C. H. Liu, R. R. Alfano

Proceedings Volume 7895, Optical Biopsy IX; 78950H (2011) https://doi.org/10.1117/12.876780
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Stokes Shift Spectroscopy (SSS) has emerged as a promising modality in the discrimination of normal from different pathological prostate tissues. Stokes shift (SS) spectra is measured by simultaneously scanning both the excitation and emission wavelengths while keeping a fixed wavelength interval Δλ=20 nm between them. Characteristic, highly resolved peaks and significant spectral differences between normal and different pathological prostate tissues were observed. The SS spectra of normal, hyperplasia and malignant tissues shows the distinct peaks around 300, 345, 440 and 510 nm is attributed to tryptophan, collagen, NADH and flavin respectively. To quantify the spectral differences between normal and different pathological prostate tissues are verified by statistical analysis.

Citation Download Citation

Ebenezar Jeyasingh, Y. Pu, W. B. Wang, C. H. Liu, and R. R. Alfano "Prostate precancer detection by Stokes Shift Spectroscopy", Proc. SPIE 7895, Optical Biopsy IX, 78950H (16 February 2011); https://doi.org/10.1117/12.876780

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KEYWORDS

Tissues

Prostate

Luminescence

Diagnostics

Spectroscopy

Collagen

Statistical analysis

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