VEGF-C as a survival factor for retinal pigment epithelial cells from photothermal stress

Brent J. Lavey; Katharine E. Sheldon; Larry E. Estlack; Kurt J. Schuster; Michael D. Barnhart; Benjamin A. Rockwell

doi:10.1117/12.872755

17 February 2011 VEGF-C as a survival factor for retinal pigment epithelial cells from photothermal stress

Brent J. Lavey, Katharine E. Sheldon, Larry E. Estlack, Kurt J. Schuster, Michael D. Barnhart, Benjamin A. Rockwell

Proceedings Volume 7897, Optical Interactions with Tissue and Cells XXII; 78971L (2011) https://doi.org/10.1117/12.872755
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Vascular endothelial growth factor (VEGF) is known for its role in neovascularization and cellular signaling pathways of sub-threshold retinal lesions. The objective of this study was to elucidate potential protection mechanisms to laser-induced heat stress utilizing an in vitro retinal model. The cell line was characterized to determine the relative abundance of VEGF-C protein. Cells, preconditioned via water bath and controls, were then exposed to 2 μm laser radiation to assess whether increases in protein production following preconditioning could confer any protection. There was no significant increase in threshold damage irradiance (ED₅₀) in the preconditioned cells versus control.

Citation Download Citation

Brent J. Lavey, Katharine E. Sheldon, Larry E. Estlack, Kurt J. Schuster, Michael D. Barnhart, and Benjamin A. Rockwell "VEGF-C as a survival factor for retinal pigment epithelial cells from photothermal stress", Proc. SPIE 7897, Optical Interactions with Tissue and Cells XXII, 78971L (17 February 2011); https://doi.org/10.1117/12.872755

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available