In-vivo three-dimensional Doppler variance imaging for tumor angiogenesis on chorioallantoic membrane

Wenjuan Qi; Gangjun Liu; Zhongping Chen; Nzola De Magalhães

doi:10.1117/12.875186

10 February 2011 In-vivo three-dimensional Doppler variance imaging for tumor angiogenesis on chorioallantoic membrane

Wenjuan Qi, Gangjun Liu, Zhongping Chen, Nzola De Magalhães

Proceedings Volume 7898, Dynamics and Fluctuations in Biomedical Photonics VIII; 78980O (2011) https://doi.org/10.1117/12.875186
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Non-invasive tumor microvasculature visualization and characterization play significant roles in the detection of tumors and importantly, for aiding in the development of therapeutic strategies. The feasibility and effectiveness of a Doppler variance standard deviation imaging method for tumor angiogenesis on chorioallantoic membrane were tested in vivo on a rat glioma F98 tumor spheroid. Utilizing a high resolution Doppler Variance Optical Coherence Tomography (DVOCT) system with A-line rate of 20 kHz, three-dimensional mapping of a tumor with a total area of 3×2.5mm² was completed within 15 seconds. The top-view image clearly visualized the complex vascular perfusion with the detection of capillaries as small as approximately 10μm. The results of the current study demonstrate the capability of the Doppler variance standard deviation imaging method as a non-invasive assessment of tumor angiogenesis, with the potential for its use in clinical settings.

Citation Download Citation

Wenjuan Qi, Gangjun Liu, Zhongping Chen, and Nzola De Magalhães "In-vivo three-dimensional Doppler variance imaging for tumor angiogenesis on chorioallantoic membrane", Proc. SPIE 7898, Dynamics and Fluctuations in Biomedical Photonics VIII, 78980O (10 February 2011); https://doi.org/10.1117/12.875186

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