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18 February 2011 High speed inverted optical-resolution photoacoustic microscopy
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Abstract
Photoacoustic microscopy (PAM) offers label-free, optical absorption contrast. A high-speed, high-resolution PAM system in an inverted microscope configuration with a laser pulse repetition rate of 100,000 Hz and a stationary ultrasonic transducer was built. Four-dimensional in vivo imaging of microcirculation in mouse skin was achieved at 18 three-dimensional volumes per second with repeated two-dimensional raster scans of 100 by 50 points. The corresponding twodimensional B-scan (50 A-lines) frame rate was 1800 Hz, and the one-dimensional A-scan rate was 90,000 Hz. The lateral resolution is 0.23±0.03 μm for Au nano-wire imaging, which is 2.0 times below the diffraction limit.
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Bin Rao, Konstantin Maslov, Amos Danielli, Ruiming Chen, K. Kirk Shung, Qifa Zhou, and Lihong V. Wang "High speed inverted optical-resolution photoacoustic microscopy", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78990T (18 February 2011); https://doi.org/10.1117/12.873568
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