Tomographic optoacoustic inversion in dynamic illumination scenarios

Thomas Jetzfellner; Amir Rosenthal; Andreas Buehler; Alexander Dima; Karl Hans Englmeier; Vasilis Ntziachristos; Daniel Razansky

doi:10.1117/12.876110

18 February 2011 Tomographic optoacoustic inversion in dynamic illumination scenarios

Thomas Jetzfellner, Amir Rosenthal, Andreas Buehler, Alexander Dima, Karl Hans Englmeier, Vasilis Ntziachristos, Daniel Razansky

Author Affiliations +

Proceedings Volume 7899, Photons Plus Ultrasound: Imaging and Sensing 2011; 78991Y (2011) https://doi.org/10.1117/12.876110
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Obtaining quantified optoacoustic reconstructions is an important and longstanding challenge, mainly caused by the complex heterogeneous structure of biological tissues as well as the lack of accurate and robust reconstruction algorithms. The recently introduced model-based inversion approaches were shown to eliminate some of reconstruction artifacts associated with the commonly used back-projection schemes, while providing an excellent platform for obtaining quantified maps of optical energy deposition in experimental configurations of various complexity. In this work, we introduce a weighted model-based approach, capable of overcoming reconstruction challenges caused by perprojection variations of object's illumination and other partial illumination effects. The universal weighting procedure is equally shown to reduce reconstruction artifacts associated with other experimental imperfections, such as non-uniform transducer sensitivity fields. Significant improvements in image fidelity and quantification are showcased both numerically and experimentally on tissue phantoms.

Citation Download Citation

Thomas Jetzfellner, Amir Rosenthal, Andreas Buehler, Alexander Dima, Karl Hans Englmeier, Vasilis Ntziachristos, and Daniel Razansky "Tomographic optoacoustic inversion in dynamic illumination scenarios", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78991Y (18 February 2011); https://doi.org/10.1117/12.876110

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