Nanoparticle heating: nanoscale to bulk effects of electromagnetically heated iron oxide and gold for biomedical applications

Zhenpeng Qin; Michael Etheridge; John C. Bischof

doi:10.1117/12.876528

23 February 2011 Nanoparticle heating: nanoscale to bulk effects of electromagnetically heated iron oxide and gold for biomedical applications

Zhenpeng Qin, Michael Etheridge, John C. Bischof

Author Affiliations +

Proceedings Volume 7901, Energy-based Treatment of Tissue and Assessment VI; 79010C (2011) https://doi.org/10.1117/12.876528
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Biomedical applications of nanoparticle heating range in scale from molecular activation (i.e. molecular beacons, protein denaturation, lipid melting and drug release), cellular heating (i.e. nanophotolysis and membrane permeability control and rupture) to whole tumor heating (deep and superficial). This work will present a review on the heating of two classes of biologically compatible metallic nanoparticles: iron oxide and gold with particular focus on spatial and temporal scales of the heating event. The size range of nanoparticles under discussion will focus predominantly in the 10 - 200 nm diameter size range. Mechanisms of heating range from Néelian and Brownian relaxation due to magnetic susceptibility at 100s of kHz, optical absorption due to VIS and NIR lasers and "Joule" heating at higher frequency RF (13.56 MHz). The heat generation of individual nanoparticles and the thermal responses at nano-, micro-, and macroscales are presented. This review will also discuss how to estimate a specific absorption rate (SAR, W/g) based on individual nanoparticles heating in bulk samples. Experimental setups are designed to measure the SAR and the results are compared with theoretical predictions.

Citation Download Citation

Zhenpeng Qin, Michael Etheridge, and John C. Bischof "Nanoparticle heating: nanoscale to bulk effects of electromagnetically heated iron oxide and gold for biomedical applications", Proc. SPIE 7901, Energy-based Treatment of Tissue and Assessment VI, 79010C (23 February 2011); https://doi.org/10.1117/12.876528

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available