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11 February 2011Dual-modality in vivo imaging for MRI detection of tumors and NIRF-guided
surgery using multi-component nanoparticles
Magnetic resonance imaging (MRI) is one of the best imaging modalities for noninvasive cancer detection but MRI does
not have enough sensitivity to delineate tumor margins during surgery. Moreover, since most surgical tools contain
metal substances, image-guided surgery is hard to perform with a MR machine using magnets. Also, MR imaging is too
slow for real-time guided-surgery. On the other hand, near infrared fluorescence (NIRF) imaging has recently received
great interest for in vivo imaging due to its high signal-to-noise ratios and short image-acquisition times. NIRF imaging
can be used to delineate tumor margins during surgery, but current NIRF imaging cannot provide the penetration depth
to detect early-stage cancer inside body. Thus, we have developed dual-modality in vivo imaging for MRI detection of
tumors and NIRF-guided surgery using multi-component nanoparticles. NIRF dye (cyanine 5.5, Cy5.5), conjugated
glycol chitosan nanoparticles (HGC) exhibited excellent tumor targeting ability with NIRF imaging. Superparamagnetic
iron oxide (SPIO) nanoparticles as a MR contrast agent were loaded into the nanoparticles, resulting in SPIO-HGC-Cy5.5
nanoparticles. SPIO-HGC-Cy5.5 nanoparticles were characterized and evaluated in mice by both NIRF and MR
imaging. Our results indicate SPIO-HGC-Cy5.5 nanoparticles have the potential for dual-modality in vivo imaging with
MRI detection of tumors and NIRF-guided surgery.
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Jaehong Key, Kwangmeyung Kim, Deepika Dhawan, Deborah W. Knapp, Ick Chan Kwon, Kuiwon Choi, James F. Leary, "Dual-modality in vivo imaging for MRI detection of tumors and NIRF-guided surgery using multi-component nanoparticles," Proc. SPIE 7908, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VIII, 790805 (11 February 2011); https://doi.org/10.1117/12.874241