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11 February 2011 A novel high-sensitive miniaturized optical system for fluorescence detection
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This paper presents a novel, high sensitive and miniaturized fluorescence detection system which integrated a LED light source, all necessary optical components and a photodiode with preamplifier into one package about 2 cm x 2 cm x 2 cm especially for the applications of lab-on-a-chip, portable bio-detection system and point-of-care diagnostic system. The prototype has been tested using the fluorescence dye 5-Carboxyfluorescein (5-FAM) dissolved into solvent DMSO (Dimethyl Sulfoxide) and diluted with DI water as the testing solution samples. Resolution approximation method is accepted to evaluate the sensitivity. The testing results prove a remarkable sensitivity at pico-scale molar, around 1.08 pM/L, which should meet the most of bio-detection requirements. This cost-effective detection system can be widely integrated to the portable device and system for fluorescent detection in biological, chemical, medical, point-of-care applications.
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Mingjin Yao and Ji Fang "A novel high-sensitive miniaturized optical system for fluorescence detection", Proc. SPIE 7908, Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications VIII, 79080X (11 February 2011);


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