Quantitative in vivo lifetime imaging using a time-domain platform with a supercontinuum tunable laser for extended spectral coverage

Niculae Mincu; Dao Chao Huang; Marilyse Piche; Guobin Ma

doi:10.1117/12.875214

11 February 2011 Quantitative in vivo lifetime imaging using a time-domain platform with a supercontinuum tunable laser for extended spectral coverage

Niculae Mincu, Dao Chao Huang, Marilyse Piche, Guobin Ma

Author Affiliations +

Proceedings Volume 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III; 79101K (2011) https://doi.org/10.1117/12.875214
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

The continuously expanding number of fluorescent probes developed for molecular imaging in vivo requires new instruments, more flexible and with higher quantification power. Responding to those requirements we propose a new instrument: it combines the sensitivity of time correlated single photon detection with the extended spectral coverage of a pulsed supercontinuum laser in a sensitive and flexible time-domain platform for in vivo molecular imaging in small animals. The performance of the system is demonstrated on a case study, using NEO-STEM-PMSR50- PEG fluorescent silica nanoprobes and sequential imaging of CD-1 nude mice.

Citation Download Citation

Niculae Mincu, Dao Chao Huang, Marilyse Piche, and Guobin Ma "Quantitative in vivo lifetime imaging using a time-domain platform with a supercontinuum tunable laser for extended spectral coverage", Proc. SPIE 7910, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications III, 79101K (11 February 2011); https://doi.org/10.1117/12.875214

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