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9 March 2011Estimation of myocardial volume at risk from CT angiography
The determination of myocardial volume at risk distal to coronary stenosis provides important information for prognosis
and treatment of coronary artery disease. In this paper, we present a novel computational framework for estimating the
myocardial volume at risk in computed tomography angiography (CTA) imagery. Initially, epicardial and endocardial
surfaces, and coronary arteries are extracted using an active contour method. Then, the extracted coronary arteries are
projected onto the epicardial surface, and each point on this surface is associated with its closest coronary artery using
the geodesic distance measurement. The likely myocardial region at risk on the epicardial surface caused by a stenosis is
approximated by the region in which all its inner points are associated with the sub-branches distal to the stenosis on the
coronary artery tree. Finally, the likely myocardial volume at risk is approximated by the volume in between the region
at risk on the epicardial surface and its projection on the endocardial surface, which is expected to yield computational
savings over risk volume estimation using the entire image volume. Furthermore, we expect increased accuracy since, as
compared to prior work using the Euclidean distance, we employ the geodesic distance in this work. The experimental
results demonstrate the effectiveness of the proposed approach on pig heart CTA datasets.
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Liangjia Zhu, Yi Gao, Vandana Mohan, Arthur Stillman, Tracy Faber, Allen Tannenbaum, "Estimation of myocardial volume at risk from CT angiography," Proc. SPIE 7963, Medical Imaging 2011: Computer-Aided Diagnosis, 79632A (9 March 2011); https://doi.org/10.1117/12.878249