Mouse whole-body organ mapping by non-rigid registration approach

Di Xiao; David Zahra; Pierrick Bourgeat; Paula Berghofer; Oscar Acosta Tamayo; Heather Green; Marie Claude Gregoire; Olivier Salvado

doi:10.1117/12.877921

9 March 2011 Mouse whole-body organ mapping by non-rigid registration approach

Di Xiao, David Zahra, Pierrick Bourgeat, Paula Berghofer, Oscar Acosta Tamayo, Heather Green, Marie Claude Gregoire, Olivier Salvado

Author Affiliations +

Proceedings Volume 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging; 79650E (2011) https://doi.org/10.1117/12.877921
Event: SPIE Medical Imaging, 2011, Lake Buena Vista (Orlando), Florida, United States

Abstract

Automatic small animal whole-body organ registration is challenging because of subject's joint structure, posture and position difference and loss of reference features. In this paper, an improved 3D shape context based non-rigid registration method is applied for mouse whole-body skeleton registration and lung registration. A geodesic path based non-rigid registration method is proposed for mouse torso skin registration. Based on the above registration methods, a novel non-rigid registration framework is proposed for mouse whole-body organ mapping from an atlas to new scanned CT data. A preliminary experiment was performed to test the method on lung and skin registration. A whole-body organ mapping was performed on three target data and the selected organs were compared with the manual outlining results. The robust of the method has been demonstrated.

Citation Download Citation

Di Xiao, David Zahra, Pierrick Bourgeat, Paula Berghofer, Oscar Acosta Tamayo, Heather Green, Marie Claude Gregoire, and Olivier Salvado "Mouse whole-body organ mapping by non-rigid registration approach", Proc. SPIE 7965, Medical Imaging 2011: Biomedical Applications in Molecular, Structural, and Functional Imaging, 79650E (9 March 2011); https://doi.org/10.1117/12.877921

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