Elastic characterization of swine aorta by scanning acoustic microscopy at 30 MHz

Christopher Blase; Amit Shelke; Tribikram Kundu; Jürgen Bereiter-Hahn

doi:10.1117/12.881330

31 March 2011 Elastic characterization of swine aorta by scanning acoustic microscopy at 30 MHz

Christopher Blase, Amit Shelke, Tribikram Kundu, Jürgen Bereiter-Hahn

Proceedings Volume 7984, Health Monitoring of Structural and Biological Systems 2011; 79840Y (2011) https://doi.org/10.1117/12.881330
Event: SPIE Smart Structures and Materials + Nondestructive Evaluation and Health Monitoring, 2011, San Diego, California, United States

Abstract

The mechanical properties of blood vessel walls are important determinants of physiology and pathology of the cardiovascular system. Acoustic imaging (B mode) is routinely used in a clinical setting to determine blood flow and wall distensibility. In this study scanning acoustic microscopy in vitro is used to determine spatially resolved tissue elastic properties. Broadband excitation of 30 MHz has been applied through scanning acoustic microscopy (SAM) for topographical imaging of swine thoracic aorta in reflection mode. Three differently treated tissue samples were investigated with SAM: a) treated with elastase to remove elastin, b) autoclaving for 5 hours to remove collagen and c) fresh controlled untreated sample as control. Experimental investigations are conducted for studying the contribution of individual protein components (elastin and collagen) to the material characteristics of the aortic wall. Conventional tensile testing has been conducted on the tissue samples to study the mechanical behavior. The mechanical properties measured by SAM and tensile testing show qualitative agreement.

Citation Download Citation

Christopher Blase, Amit Shelke, Tribikram Kundu, and Jürgen Bereiter-Hahn "Elastic characterization of swine aorta by scanning acoustic microscopy at 30 MHz", Proc. SPIE 7984, Health Monitoring of Structural and Biological Systems 2011, 79840Y (31 March 2011); https://doi.org/10.1117/12.881330

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