Revealing some virus infections by lymphocyte laser scattering

Gennady I. Ruban; Vladimir V. Berdnik; Dmitry V. Marinitch; Natalia V. Goncharova; Valery A. Loiko

doi:10.1117/12.881925

7 February 2011 Revealing some virus infections by lymphocyte laser scattering

Gennady I. Ruban, Vladimir V. Berdnik, Dmitry V. Marinitch, Natalia V. Goncharova, Valery A. Loiko

Proceedings Volume 7994, LAT 2010: International Conference on Lasers, Applications, and Technologies; 79940K (2011) https://doi.org/10.1117/12.881925
Event: International Conference on Coherent and Nonlinear Optics (ICONO 2010) and International Conference on Lasers, Applications and Technologies (LAT 2010), 2010, Kazan, Russian Federation

Abstract

Light scattering patterns have been calculated for a simple optical model constructed for single smooth and nonsmooth lymphocytes of healthy and infected individuals. It has been shown that the smooth and nonsmooth cells can be resolved using the intensities of the sideward and backward scattered light. We have found by calculations and validated by the flow-cytometer experiments that intensity distributions for the cells of lymphocyte populations can be used as a preliminary signatures of some virus infections. Potential biomedical applications of the findings for label-free flowcytometry detecting of individuals infected with viruses of hepatitises B or C and some others viruses are presented.

Citation Download Citation

Gennady I. Ruban, Vladimir V. Berdnik, Dmitry V. Marinitch, Natalia V. Goncharova, and Valery A. Loiko "Revealing some virus infections by lymphocyte laser scattering", Proc. SPIE 7994, LAT 2010: International Conference on Lasers, Applications, and Technologies, 79940K (7 February 2011); https://doi.org/10.1117/12.881925

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