The progress in the laser-driven proton acceleration experiment JAEA with table-tip Ti:Sappire laser system

M. Nishiuchi; K. Ogura; A. S. Pirozhkov; T. Tanimoto; A. Yogo; H. Sakaki; T. Hori; Y. Fukuda; M. Kanasaki; A. Sagisaka; M. Tampo; H. Kiriyama; T. Shimomura; K. Kondo; S. Kawanishi; C. Brenner; D. Neely

doi:10.1117/12.886429

11 May 2011 The progress in the laser-driven proton acceleration experiment JAEA with table-tip Ti:Sappire laser system

M. Nishiuchi, K. Ogura, A. S. Pirozhkov, T. Tanimoto, A. Yogo, H. Sakaki, T. Hori, Y. Fukuda, M. Kanasaki, A. Sagisaka, M. Tampo, H. Kiriyama, T. Shimomura, K. Kondo, S. Kawanishi, C. Brenner, D. Neely

Author Affiliations +

Proceedings Volume 8079, Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles; 80790B (2011) https://doi.org/10.1117/12.886429
Event: SPIE Optics + Optoelectronics, 2011, Prague, Czech Republic

Abstract

This paper presents the experimental investigation of laser-driven proton acceleration using a table top Ti:Sapphire laser system interacting with the thin-foil targets during the course of medical application of the laser-driven proton beam. The proton beam with maximum energy of upto 14~MeV is generated in 60 TW mode. The number of protons at ~10 MeV is estimated to be over 10⁵ proton/sr/MeV/shot with beam having half divergence angle of 5~degree. If 10 Hz operation is assumed 2 Gy dose is possible to irradiate during 10 min onto a ~1 mm tumor just under the skin. In contrast to the previous condition of our apparatus with which we demonstrated the DNA double-strand breaking by irradiating the laser-driven proton beam onto the human cancer cells in-vitro test, the result reported here has significant meaning in the sense that pre-clinical in-vivo test can be started by irradiating the laser-driven proton beam onto the skin of the mouse, which is unavoidable step before the real radiation therapy.

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M. Nishiuchi, K. Ogura, A. S. Pirozhkov, T. Tanimoto, A. Yogo, H. Sakaki, T. Hori, Y. Fukuda, M. Kanasaki, A. Sagisaka, M. Tampo, H. Kiriyama, T. Shimomura, K. Kondo, S. Kawanishi, C. Brenner, and D. Neely "The progress in the laser-driven proton acceleration experiment JAEA with table-tip Ti:Sappire laser system", Proc. SPIE 8079, Laser Acceleration of Electrons, Protons, and Ions; and Medical Applications of Laser-Generated Secondary Sources of Radiation and Particles, 80790B (11 May 2011); https://doi.org/10.1117/12.886429

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