Nano-sensitizers for multi-modality optical diagnostic imaging and therapy of cancer

Malini Olivo; Sasidharan Swarnalatha Lucky; Ramaswamy Bhuvaneswari; Nagamani Dendukuri

doi:10.1117/12.890850

8 June 2011 Nano-sensitizers for multi-modality optical diagnostic imaging and therapy of cancer

Malini Olivo, Sasidharan Swarnalatha Lucky, Ramaswamy Bhuvaneswari, Nagamani Dendukuri

Proceedings Volume 8087, Clinical and Biomedical Spectroscopy and Imaging II; 80870T (2011) https://doi.org/10.1117/12.890850
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

We report novel bioconjugated nanosensitizers as optical and therapeutic probes for the detection, monitoring and treatment of cancer. These nanosensitisers, consisting of hypericin loaded bioconjugated gold nanoparticles, can act as tumor cell specific therapeutic photosensitizers for photodynamic therapy coupled with additional photothermal effects rendered by plasmonic heating effects of gold nanoparticles. In addition to the therapeutic effects, the nanosensitizer can be developed as optical probes for state-of-the-art multi-modality in-vivo optical imaging technology such as in-vivo 3D confocal fluorescence endomicroscopic imaging, optical coherence tomography (OCT) with improved optical contrast using nano-gold and Surface Enhanced Raman Scattering (SERS) based imaging and bio-sensing. These techniques can be used in tandem or independently as in-vivo optical biopsy techniques to specifically detect and monitor specific cancer cells in-vivo. Such novel nanosensitizer based optical biopsy imaging technique has the potential to provide an alternative to tissue biopsy and will enable clinicians to make real-time diagnosis, determine surgical margins during operative procedures and perform targeted treatment of cancers.

Citation Download Citation

Malini Olivo, Sasidharan Swarnalatha Lucky, Ramaswamy Bhuvaneswari, and Nagamani Dendukuri "Nano-sensitizers for multi-modality optical diagnostic imaging and therapy of cancer", Proc. SPIE 8087, Clinical and Biomedical Spectroscopy and Imaging II, 80870T (8 June 2011); https://doi.org/10.1117/12.890850

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available