Surface-enhanced Raman spectroscopy differences of saliva between lung cancer patients and normal people

Xiaozhou Li; Tianyue Yang; Siqi Li; Ting Yu

doi:10.1117/12.889320

14 June 2011 Surface-enhanced Raman spectroscopy differences of saliva between lung cancer patients and normal people

Xiaozhou Li, Tianyue Yang, Siqi Li, Ting Yu

Proceedings Volume 8087, Clinical and Biomedical Spectroscopy and Imaging II; 808722 (2011) https://doi.org/10.1117/12.889320
Event: European Conferences on Biomedical Optics, 2011, Munich, Germany

Abstract

Surface enhanced Raman spectroscopy (SERS) has shown the advantage of detecting low concentration biofluids presently. Saliva SERS of 21 lung cancer patients and 22 normal people were measured and differentiated in this paper. Intensities of most peaks of lung cancer patients are weaker than that of normal people, some are stronger but with a small change rate. Those peaks were assigned to proteins and nucleic acids which indicate a corresponding decrease of substance in saliva. Principal component analysis (PCA) and linear discriminant analysis (LDA) were used to deduce and discriminate the two groups of data, resulted in accuracy, sensitivity, and specificity being 84%, 94%, and 81%, respectively. In conclusion, SERS of saliva has the ability of predicting lung cancer.

Citation Download Citation

Xiaozhou Li, Tianyue Yang, Siqi Li, and Ting Yu "Surface-enhanced Raman spectroscopy differences of saliva between lung cancer patients and normal people", Proc. SPIE 8087, Clinical and Biomedical Spectroscopy and Imaging II, 808722 (14 June 2011); https://doi.org/10.1117/12.889320

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