Two-photon absorbing chromophores for photodynamic therapy: molecular engineering and in vivo applications

Cyrille Monnereau; Thibault Gallavardin; Chloé Armagnat; Pierre-Henri Lanoé; Olivier Maury; Sophie Marotte; Yann Leverrier; Patrice L. Baldeck; Chantal Andraud

doi:10.1117/12.895984

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15 September 2011 Two-photon absorbing chromophores for photodynamic therapy: molecular engineering and in vivo applications

Cyrille Monnereau, Thibault Gallavardin, Chloé Armagnat, Pierre-Henri Lanoé, Olivier Maury, Sophie Marotte, Yann Leverrier, Patrice L. Baldeck, Chantal Andraud

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Proceedings Volume 8103, Nanobiosystems: Processing, Characterization, and Applications IV; 81030N (2011) https://doi.org/10.1117/12.895984
Event: SPIE NanoScience + Engineering, 2011, San Diego, California, United States

Abstract

Recent examples of our works in the field of molecular engineering of chromophores for two-photon photodynamic therapy (PDT), and their vectorization into biological medium are presented and discussed. In a first section of this article, we show that a commercial amphiphilic diblock copolymer can be used as a micellar container for efficient delivery of s standard two-photon PDT sensitizer into cells. In a second section, we show how a simple molecular engineering strategy can be used to improve the performances of two-photon PDT sensitizer in the biological transparency-window.

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Cyrille Monnereau, Thibault Gallavardin, Chloé Armagnat, Pierre-Henri Lanoé, Olivier Maury, Sophie Marotte, Yann Leverrier, Patrice L. Baldeck, and Chantal Andraud "Two-photon absorbing chromophores for photodynamic therapy: molecular engineering and in vivo applications", Proc. SPIE 8103, Nanobiosystems: Processing, Characterization, and Applications IV, 81030N (15 September 2011); https://doi.org/10.1117/12.895984

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