Translator Disclaimer
26 September 2011 Controlled skeletal progenitor cell migration on nanostructured porous silicon/silicon micropatterns
Author Affiliations +
In this work nanostructured porous silicon (nanoPS) was used for the fabrication of surface micropatterns aiming at controlling cell adhesion and migration. In particular, surface patterns of nanoPS and Si were engineered by high-energy ion-beam irradiation and subsequent anodization. It was found that human skeletal progenitor cells are sensitive to oneand two-dimensional patterns and that focal adhesion is inhibited on nanoPS areas. In spite of this anti-fouling characteristics, studies on patterns with reduced Si areas show that cells conform to nanoPS pathways favoring migration through cell protrusion, body translocation and tail retraction from two parallel Si traction rails. Moreover, migration can be blocked and cells tend to arrange when grid patterns with the appropriate dimensions are fabricated. The experimental results confirm that progenitor cells are able to exploit nanoPS anti-fouling designs by adapting to it for migration purposes.
© (2011) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.
V. Torres-Costa, V. Sánchez-Vaquero, Á. Muñoz-Noval, L. González-Méndez, E. Punzón-Quijorna, D. Gallach-Pérez, M. Manso-Silván, G. Martínez-Muñoz, A. Climent-Font, J. P. García-Ruiz, and R. J. Martín-Palma "Controlled skeletal progenitor cell migration on nanostructured porous silicon/silicon micropatterns", Proc. SPIE 8104, Nanostructured Thin Films IV, 81040O (26 September 2011);

Back to Top