Quantitative measurement of cerebral blood flow during hypothermia with a time-resolved near-infrared technique

Mohammad Fazel Bakhsheshi; Mamadou Diop; Keith St Lawrence; Ting-Yim Lee

doi:10.1117/12.909734

9 February 2012 Quantitative measurement of cerebral blood flow during hypothermia with a time-resolved near-infrared technique

Mohammad Fazel Bakhsheshi, Mamadou Diop, Keith St Lawrence, Ting-Yim Lee

Author Affiliations +

Proceedings Volume 8207, Photonic Therapeutics and Diagnostics VIII; 82074R (2012) https://doi.org/10.1117/12.909734
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Hypothermia, in which the brain is cooled to 32-33 °C, has been shown to be neuroprotective for brain injury caused by hypoxia-ischemia, head trauma, or neonatal asphyxia. Neuroprotective effect of Hypothermia is partly due to suppression of brain metabolism and cerebral blood flow (CBF). The ability to measure CBF at the bedside provides a means of detecting, and thereby preventing, secondary ischemia during neuro intensive care before brain injury occurs. The purpose of the present study is to investigate the ability of a time-resolved near-infrared (TR-NIR) bolus-tracking method using indocyanine green as an intravascular flow tracer to measure CBF during cooling in a newborn animal model. For validation, CBF was independently measured by computed tomography (CT) perfusion. The results show a good agreement between CBF obtained with the two methods (R² ≈ 0.84, Δ ≈ 5.84 ml. min ^-1.100 g ^-1, 32-38.5 °C), demonstrating the ability of the TR-NIR technique to non-invasively measure absolute CBF in-vivo during dynamic hypothermia. The TR-NIR technique reveals that CBF decreases from 54.3 ± 5.4 ml. min ^-1.100 g ^-1, at normothermia (T_brain of 38.5 °C), to 33.8 ± 0.9 ml. min ^-1.100 g ^-1 at T_brain of 32 °C during the hypothermia treatment.

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Mohammad Fazel Bakhsheshi, Mamadou Diop, Keith St Lawrence, and Ting-Yim Lee "Quantitative measurement of cerebral blood flow during hypothermia with a time-resolved near-infrared technique", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82074R (9 February 2012); https://doi.org/10.1117/12.909734

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