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9 February 2012 Dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) of photodynamic therapy (PDT) outcome and associated changes in the blood-brain barrier following Pc 4-PDT of glioma in an athymic nude rat model
Vaijayantee Belle, Ali Anka, Nathan Cross, Paul Thompson, Eric Mott, Rahul Sharma, Kayla Gray, Ruozhen Zhang, Yueshuo Xu, Jiayang Sun, Chris A. Flask, Nancy L. Oleinick, David Dean
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Proceedings Volume 8207, Photonic Therapeutics and Diagnostics VIII; 82074T (2012) https://doi.org/10.1117/12.909280
Event: SPIE BiOS, 2012, San Francisco, California, United States
Abstract
Introduction: Dynamic Contrast-Enhanced-Magnetic Resonance Imaging (DCE-MRI) appears to provide an unambiguous means of tracking the outcome of photodynamic therapy (PDT) of brain tumors with the photosensitizer Pc 4. The increase in Gd enhancement observed after Pc 4-PDT may be due to a temporary opening of the blood-brain-barrier which, as noted by others, may offer a therapeutic window. Methods: We injected 2.5 x 105 U87 cells into the brains of 9 athymic nude rats. After 8-9 days peri-tumor DCE-MRI images were acquired on a 7.0 T microMRI scanner before and after the administration of 150 μL Gd. DCE-MRI scans were repeated three times following Pc 4-PDT. Results: The average, normalized peak enhancement in the tumor region, approximately 30-90 seconds after Gd administration, was 1.31 times greater than baseline (0.03 Standard Error [SE]) prior to PDT and was 1.44 (0.02 SE) times baseline in the first Post-PDT scans (Day 11), a statistically significant (p ≈ 0.014, N=8) increase over the Pre- PDT scans, and was 1.38 (0.02 SE) times baseline in the second scans (Day 12), also a statistically significant (p ≈ 0.008, N=7) increase. Observations were mixed in the third Post-PDT scans (Day 13), averaging 1.29 (0.03 SE) times baseline (p ≈ 0.66, N=7). Overall a downward trend in enhancement was observed from the first to the third Post-PDT scans. Discussion: DCE-MRI may provide an unambiguous indication of brain tumor PDT outcome. The initial increase in DCE-MRI signal may correlate with a temporary, PDT-induced opening of the blood-brain-barrier, creating a potential therapeutic window.
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Vaijayantee Belle, Ali Anka, Nathan Cross, Paul Thompson, Eric Mott, Rahul Sharma, Kayla Gray, Ruozhen Zhang, Yueshuo Xu, Jiayang Sun, Chris A. Flask, Nancy L. Oleinick, and David Dean "Dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) of photodynamic therapy (PDT) outcome and associated changes in the blood-brain barrier following Pc 4-PDT of glioma in an athymic nude rat model", Proc. SPIE 8207, Photonic Therapeutics and Diagnostics VIII, 82074T (9 February 2012); https://doi.org/10.1117/12.909280
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KEYWORDS
Photodynamic therapy
Tumors
Brain
Tissues
Neuroimaging
Resonance enhancement
Error analysis
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