Estimation of surface wave propagation in mouse cornea

Ravi Kiran Manapuram; Floredes M. Menodiado; Phiet Truong; Salavat Aglyamov; Stanislav Emelianov; Michael Twa; Kirill V. Larin

doi:10.1117/12.909229

9 March 2012 Estimation of surface wave propagation in mouse cornea

Ravi Kiran Manapuram, Floredes M. Menodiado, Phiet Truong, Salavat Aglyamov, Stanislav Emelianov, Michael Twa, Kirill V. Larin

Author Affiliations +

Proceedings Volume 8209, Ophthalmic Technologies XXII; 82090S (2012) https://doi.org/10.1117/12.909229
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

In this paper, we report the use of phase stabilized swept source optical coherence tomography (PhSSSOCT) for the measurement of surface mechanical wave propagation in ocular tissue in-situ. Mechanical wave propagation was measured in the mouse cornea for both young and older mice to assess tissue properties as a function of age. The measurements were performed by inducing low amplitude (< 100 μm) waves and measuring the wave attenuation at spatially distributed points using a phase-sensitive analysis of OCT signals. Obtained results indicate that the attenuation of the wave amplitude was 0.27 μm/mm in the one month-old mouse cornea and 0.37 μm/mm for 9 month old mice (and presumably of different stiffness for 1 month and 9 months old). Results also suggest that PhS-SSOCT is capable of measuring the changes in the wave amplitude as small as 0.03 μm (limited by the phase stability of the system) that allowed the measurements with a very low amplitude excitation wave, thus making the method minimally invasive. Therefore, this method could potentially be used to assess tissue biomechanical properties and to reconstruct stiffness maps of the cornea.

Citation Download Citation

Ravi Kiran Manapuram, Floredes M. Menodiado, Phiet Truong, Salavat Aglyamov, Stanislav Emelianov, Michael Twa, and Kirill V. Larin "Estimation of surface wave propagation in mouse cornea", Proc. SPIE 8209, Ophthalmic Technologies XXII, 82090S (9 March 2012); https://doi.org/10.1117/12.909229

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