Does tropicamide affect choroidal blood flow in humans? a laser Doppler flowmetry study

Nithiyanantham Palanisamy; Charles E. Riva; Luigi Rovati; Mauro Cellini; Corrado Gizzi; Ernesto Strobbe; Emilio C. Campos

doi:10.1117/12.906605

9 March 2012 Does tropicamide affect choroidal blood flow in humans? a laser Doppler flowmetry study

Nithiyanantham Palanisamy, Charles E. Riva, Luigi Rovati, Mauro Cellini, Corrado Gizzi, Ernesto Strobbe, Emilio C. Campos

Author Affiliations +

Proceedings Volume 8209, Ophthalmic Technologies XXII; 82091M (2012) https://doi.org/10.1117/12.906605
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

The measurement of blood flow in the ocular fundus is of scientific and clinical interest. Investigating ocular blood flow in the choroid may be important to understand the pathogenesis of numerous ocular diseases, such as glaucoma or agerelated macular degeneration (AMD). Laser Doppler flowmetry (LDF) was applied to measure relative velocity, volume and flux of red blood cells in the tissues of human eye. Its main application lies in the possibility of assessing alterations in blood flow early in the course of diseases. The purpose of the present study was to investigate the effect of pupil dilatation with one drop of 1% tropicamide on blood flow in the foveal region of the choroid of the human fundus. The blood flow parameters were measured in 24 eyes during 30 minutes (one measurement in every 3 minutes) after the application of the drop. Since the Doppler parameters depend on the scattering geometry, which may change as the pupil dilates; an artificial pupil of 4mm in diameter was placed directly in front the eye. Following the administration of tropicamide the mean pupil diameter was increased from 3.29 mm to 8.25 mm (P<0.0001, Paired student t-test). In comparison to the baseline values, the data shows no significant increases were observed in velocity, volume, and flow with 4 mm artificial pupil (0.2%, 1.3%, 0.8% respectively) and a statistically significant increases were observed without artificial pupil (10.7%, 13.9%, 12.8% respectively) following the application of tropicamide.

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Nithiyanantham Palanisamy, Charles E. Riva, Luigi Rovati, Mauro Cellini, Corrado Gizzi, Ernesto Strobbe, and Emilio C. Campos "Does tropicamide affect choroidal blood flow in humans? a laser Doppler flowmetry study", Proc. SPIE 8209, Ophthalmic Technologies XXII, 82091M (9 March 2012); https://doi.org/10.1117/12.906605

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KEYWORDS

Blood circulation

Doppler effect

Eye

Digital signal processing

Blood

Light scattering

Tissues

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