PDT: loss of autophagic cytoprotection after lysosomal photodamage

David Kessel; Michael Price

doi:10.1117/12.905286

13 February 2012 PDT: loss of autophagic cytoprotection after lysosomal photodamage

David Kessel, Michael Price

Proceedings Volume 8210, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXI; 821002 (2012) https://doi.org/10.1117/12.905286
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Photodynamic therapy is known to evoke both autophagy and apoptosis. Apoptosis is an irreversible death pathway while autophagy can serve a cytoprotective function. In this study, we examined two photosensitizing agents that target lysosomes, although they differ in the reactive oxygen species (ROS) formed during irradiation. With both agents, the 'shoulder' on the PDT dose-response curve was substantially attenuated, consistent with loss of a cytoprotective pathway. In contrast, this 'shoulder' is commonly observed when PDT targets mitochondria or the ER. We propose that lysosomal targets may offer the possibility of promoting PDT efficacy by eliminating a potentially protective pathway.

Citation Download Citation

David Kessel and Michael Price "PDT: loss of autophagic cytoprotection after lysosomal photodamage", Proc. SPIE 8210, Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XXI, 821002 (13 February 2012); https://doi.org/10.1117/12.905286

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