In vitro observation of cartilage-degeneration progression by Fourier-domain OCT

Ulrich Marx; Robert Schmitt; Sven Nebelung; Markus Tingart; Christian Lüring; Björn Rath

doi:10.1117/12.907756

28 February 2012 In vitro observation of cartilage-degeneration progression by Fourier-domain OCT

Ulrich Marx, Robert Schmitt, Sven Nebelung, Markus Tingart, Christian Lüring, Björn Rath

Proceedings Volume 8214, Advanced Biomedical and Clinical Diagnostic Systems X; 82140X (2012) https://doi.org/10.1117/12.907756
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Optical Coherence Tomography (OCT) as emerging clinical diagnostic imaging technology for dermatology and other semitransparent tissues has shown high potential in monitoring and evaluating the inner structure of articular cartilages. Since novel therapies for the limitation of cartilage degeneration in early stages of osteoarthritis are available, the early minimal invasive diagnosis of cartilage degradation is clinically essential for further treatment options. With the advancing performance and thus diagnostic opportunities of 3D-OCT devices, we carried out a systematic study by monitoring arthrotic alterations of porcine osteochondral explants that are mechanically induced under traumatic impaction. As for in-vitro tomographic imaging we utilized two OCT devices, a Thorlabs FD-OCT device with 92KHz A-scan rate and 1310nm as central wavelength and a self-developed FD-OCT device at 840nm central wavelength. This allows the comparison in image contrast and optical penetration of cartilage tissue between these two spectral bandwidths. Further we analyzed human biopsies of articular cartilages with various degrees of osteoarthritis. The 2D and 3D OCT tomograms are characterized qualitatively regarding the inner tissue structure and quantitatively regarding the tissue absorption parameters. Therefore, we are developing image processing algorithms for the automated monitoring of cartilage tissue. A scoring system for 3D-monitoring allows the characterization of the probe volume regarding the morphological structure and tissue compactness by processing the C - scan data.

Citation Download Citation

Ulrich Marx, Robert Schmitt, Sven Nebelung, Markus Tingart, Christian Lüring, and Björn Rath "In vitro observation of cartilage-degeneration progression by Fourier-domain OCT", Proc. SPIE 8214, Advanced Biomedical and Clinical Diagnostic Systems X, 82140X (28 February 2012); https://doi.org/10.1117/12.907756

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available