Coaxial electrospray for multimodal imaging and image-guided therapy

Ting Si; Leilei Zhang; Guangbin Li; Cynthia J. Roberts; Laibin Jia; Xiezhen Yin; Ronald Xu

doi:10.1117/12.909383

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29 February 2012 Coaxial electrospray for multimodal imaging and image-guided therapy

Ting Si, Leilei Zhang, Guangbin Li, Cynthia J. Roberts, Laibin Jia, Xiezhen Yin, Ronald Xu

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Proceedings Volume 8216, Multimodal Biomedical Imaging VII; 82160M (2012) https://doi.org/10.1117/12.909383
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Recent development in multimodal imaging and image-guided therapy requires multifunctional microparticles that encapsulate several imaging and therapeutic agents in the same carrier for simultaneous detection and treatment of the diseases. However, commonly used microfabrication processes for these microparticles have multiple limitations such as the low encapsulation efficiency and the loss of bioactivity for the encapsulated biological cargos. To overcome these limitations, we have carried out both the experimental and the theoretical studies on coaxial electrospray of poly(lactide-co-glycolide) PLGA microparticles. On the experimental side, a coaxial electrospray setup has been developed and tested. The setup consists of a customized coaxial needle assembly, two ring electrodes, two high-voltage power supplies, two syringe infusion pumps, a particle collection reservoir, and a process monitoring system. On the theoretical side, a classical normal mode method has been used for instability analysis of the coaxial electrified jet based on the experimental parameters. The effects of different dimensionless process parameters on the formation of different unstable modes have also been studied. The reported research represents the first step toward the quantitative control and optimization of the coaxial electrospray process for the fabrication of multifunctional microparticles in multimodal imaging and image-guided therapy.

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Ting Si, Leilei Zhang, Guangbin Li, Cynthia J. Roberts, Laibin Jia, Xiezhen Yin, and Ronald Xu "Coaxial electrospray for multimodal imaging and image-guided therapy", Proc. SPIE 8216, Multimodal Biomedical Imaging VII, 82160M (29 February 2012); https://doi.org/10.1117/12.909383

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