On the potential of using photoacoustic spectroscopy for monitoring red blood cell aggregation

Eno Hysi; Ratan K. Saha; Michael C. Kolios

doi:10.1117/12.928257

15 February 2012 On the potential of using photoacoustic spectroscopy for monitoring red blood cell aggregation

Eno Hysi, Ratan K. Saha, Michael C. Kolios

Proceedings Volume 8222, Dynamics and Fluctuations in Biomedical Photonics IX; 82220Q (2012) https://doi.org/10.1117/12.928257
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

In this paper we examine the potential of using photoacoustic (PA) spectroscopy for the monitoring of red blood cell (RBC) aggregation phenomena. The process of RBC aggregation has been shown to occur during periods of increased plasma fibrinogen concentration and periods of decreased blood flow (leading to diminished shear forces on the aggregates). Current techniques used to monitor RBC aggregation are invasive and do not provide an accurate assessment of the aggregation process in-vivo. We present a theoretical model for investigating the potential of PA spectroscopy for detecting and characterizing the aggregation phenomenon. We show that the signal strength increases with RBC aggregation. Experimental confirmation of the theoretical predictions is provided. Our theoretical and experimental results suggest the PA spectroscopy is capable of monitoring RBC aggregation and providing important information about changes that occur during the aggregation process as it pertains to the dynamics of aggregate formation.

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Eno Hysi, Ratan K. Saha, and Michael C. Kolios "On the potential of using photoacoustic spectroscopy for monitoring red blood cell aggregation", Proc. SPIE 8222, Dynamics and Fluctuations in Biomedical Photonics IX, 82220Q (15 February 2012); https://doi.org/10.1117/12.928257

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KEYWORDS

Blood

Transducers

Spectroscopy

Tissue optics

Ultrasonography

Photoacoustic spectroscopy

Absorption

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