Photoacoustic imaging of functional domains in primary motor cortex in rhesus macaques

Janggun Jo; Hongyu Zhang; Paul Cheney; Xinmai Yang

doi:10.1117/12.909191

23 February 2012 Photoacoustic imaging of functional domains in primary motor cortex in rhesus macaques

Janggun Jo, Hongyu Zhang, Paul Cheney, Xinmai Yang

Proceedings Volume 8223, Photons Plus Ultrasound: Imaging and Sensing 2012; 822308 (2012) https://doi.org/10.1117/12.909191
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Functional detection in primate brains has particular advantages because of the similarity between non-human primate brain and human brain and the potential for relevance to a wide range of conditions such as stroke and Parkinson's disease. In this research, we used photoacoustic imaging (PAI) technique to detect functional changes in primary motor cortex of awake rhesus monkeys. We observed strong increases in photoacoustic signal amplitude during both passive and active forelimb movement, which indicates an increase in total hemoglobin concentration resulting from activation of primary motor cortex. Further, with PAI approach, we were able to obtain depthresolved functional information from primary motor cortex. The results show that PAI can reliably detect primary motor cortex activation associated with forelimb movement in rhesus macaques with a minimal-invasive approach.

Citation Download Citation

Janggun Jo, Hongyu Zhang, Paul Cheney, and Xinmai Yang "Photoacoustic imaging of functional domains in primary motor cortex in rhesus macaques", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 822308 (23 February 2012); https://doi.org/10.1117/12.909191

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KEYWORDS

Brain

Photoacoustic imaging

Photoacoustic spectroscopy

Neuroimaging

Imaging systems

3D acquisition

Fiber lasers

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