23 February 2012Clinical feasibility study of combined optoacoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors
Jason Zalev,1 Don Herzog,1 Bryan Clingman,1 Tom Miller,1 Kenneth Kist,2 N. Carol Dornbluth,2 B. Michelle McCorvey,2 Pamela Otto,2 Sergey Ermilov,3 Vyacheslav Nadvoretsky,3 Andre Conjusteau,3 Richard Su,3 Dmitri Tsyboulski,3 Alexander Oraevsky3
1Seno Medical Instruments, Inc. (United States) 2The Univ. of Texas Health Science Ctr. at San Antonio (United States) 3TomoWave Labs., Inc. (United States)
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Two-dimensional optoacoustic imaging with a hand-held probe operated in backward mode is being developed
for diagnostic imaging of breast cancer to evaluate the feasibility of a dual-modality optoacoustic plus ultrasonic
system that maps functional information of anatomical tissue structures with ultrasonic resolution. Tissue is
illuminated at 757nm and 1064nm for optical contrast between hypoxic blood of breast carcinomas and normally
oxygenated blood in benign masses. The system is optimized and calibrated in phantoms for a pilot clinical
study of patients with breast masses suspected for malignancy. Capability of the non-invasive system to improve
detection and diagnosis of breast tumors is discussed.
Jason Zalev,Don Herzog,Bryan Clingman,Tom Miller,Kenneth Kist,N. Carol Dornbluth,B. Michelle McCorvey,Pamela Otto,Sergey Ermilov,Vyacheslav Nadvoretsky,Andre Conjusteau,Richard Su,Dmitri Tsyboulski, andAlexander Oraevsky
"Clinical feasibility study of combined optoacoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82230A (23 February 2012); https://doi.org/10.1117/12.910968
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Jason Zalev, Don Herzog, Bryan Clingman, Tom Miller, Kenneth Kist, N. Carol Dornbluth, B. Michelle McCorvey, Pamela Otto, Sergey Ermilov, Vyacheslav Nadvoretsky, Andre Conjusteau, Richard Su, Dmitri Tsyboulski, Alexander Oraevsky, "Clinical feasibility study of combined optoacoustic and ultrasonic imaging modality providing coregistered functional and anatomical maps of breast tumors," Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82230A (23 February 2012); https://doi.org/10.1117/12.910968