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23 February 2012 Quantification of optical absorption coefficient from acoustic spectra in the optical diffusive regime using photoacoustic microscopy
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Abstract
Photoacoustic (PA) tomography (PAT) can image optical absorption contrast with ultrasonic spatial resolution in the optical diffusive regime. Multi-wavelength PAT can noninvasively monitor hemoglobin oxygen saturation (sO2) with high sensitivity and fine spatial resolution. However, accurate quantification in PAT requires knowledge of the optical fluence distribution, acoustic wave attenuation, and detection system bandwidth. We propose a method to circumvent this requirement using acoustic spectra of PA signals acquired at two optical wavelengths. With the acoustic spectral method, the absorption coefficients of an oxygenated bovine blood phantom at 560 and 575 nm were quantified with errors of ><5%.
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Zijian Guo, Christopher Favazza, and Lihong V. Wang "Quantification of optical absorption coefficient from acoustic spectra in the optical diffusive regime using photoacoustic microscopy", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82234C (23 February 2012); https://doi.org/10.1117/12.906787
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