Magnetic resonance thermometry for monitoring photothermal effects of interstitial laser irradiation

Jessica Goddard; Jessnie Jose; Daniel Figueroa; Kelvin Le; Hong Liu; Robert E. Nordquist; Tomas Hode; Wei R. Chen

doi:10.1117/12.906555

9 February 2012 Magnetic resonance thermometry for monitoring photothermal effects of interstitial laser irradiation

Jessica Goddard, Jessnie Jose, Daniel Figueroa, Kelvin Le, Hong Liu, Robert E. Nordquist, Tomas Hode, Wei R. Chen

Proceedings Volume 8224, Biophotonics and Immune Responses VII; 82240A (2012) https://doi.org/10.1117/12.906555
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Selective photothermal interaction using dye-assisted non-invasive laser irradiation has limitations when treating deeper tumors or when the overlying skin is heavily pigmented. We developed an interstitial laser irradiation method to induce the desired photothermal effects. An 805-nm near-infrared laser with a cylindrical diffuser was used to treat rat mammary tumors by placing the active tip of the fiber inside the target tumors. Three different power settings (1.0 to 1.5 watts) were applied to treat animal tumors with an irradiation duration of 10 minutes. The temperature distributions of the treated tumors were measured by a 7.1-Tesla magnetic resonance imager using proton resonance frequency (PRF) method. Three-dimensional temperature profiles were reconstructed and assessed using PRF. This is the first time a 7.1-Tesla magnetic resonance imager has been used to monitor interstitial laser irradiation via PRF. This study provides a basic understanding of the photothermal interaction needed to control the thermal damage inside tumor using interstitial laser irradiation. It also shows that PRF can be used effectively in monitoring photothermal interaction. Our long-term goal is to develop a PRF-guided laser therapy for cancer treatment.

Citation Download Citation

Jessica Goddard, Jessnie Jose, Daniel Figueroa, Kelvin Le, Hong Liu, Robert E. Nordquist, Tomas Hode, and Wei R. Chen "Magnetic resonance thermometry for monitoring photothermal effects of interstitial laser irradiation", Proc. SPIE 8224, Biophotonics and Immune Responses VII, 82240A (9 February 2012); https://doi.org/10.1117/12.906555

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