Silica suspended waveguide splitter-based biosensor

M. C. Harrison; R. M. Hawk; A. M. Armani

doi:10.1117/12.907393

2 February 2012 Silica suspended waveguide splitter-based biosensor

M. C. Harrison, R. M. Hawk, A. M. Armani

Proceedings Volume 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV; 82290E (2012) https://doi.org/10.1117/12.907393
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Recently, a novel integrated optical waveguide 50/50 splitter was developed. It is fabricated using standard lithographic methods, a pair of etching steps and a laser reflow step. However, unlike other integrated waveguide splitters, the waveguide is elevated off of the silicon substrate, improving its interaction with biomolecules in solution and in a flow field. Additionally, because it is fabricated from silica, it has very low optical loss, resulting in a high signal-to-noise ratio, making it ideal for biosensing. By functionalizing the device using an epoxy-silane method using small samples and confining the protein solutions to the device, we enable highly efficient detection of CREB with only 1 μL of solution. Therefore, the waveguide coupler sensor is representative of the next generation of ultra-sensitive optical biosensors, and, when combined with microfluidic capabilities, it will be an ideal candidate for a more fully-realized lab-on-a-chip device.

Citation Download Citation

M. C. Harrison, R. M. Hawk, and A. M. Armani "Silica suspended waveguide splitter-based biosensor", Proc. SPIE 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV, 82290E (2 February 2012); https://doi.org/10.1117/12.907393

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