Spectroscopic tomography of biological tissues with the near-infrared radiation for the non-invasive measurement of the biogenic-substances

Daisuke Kojima; Takashi Takuma; Asuka Inui; Wei Qi; Ryosuke Tsutsumi; Takehiko Yuzuriha; Hiroyasu Kagiyama; Akira Nishiyama; Ichirou Ishimaru

doi:10.1117/12.907892

2 February 2012 Spectroscopic tomography of biological tissues with the near-infrared radiation for the non-invasive measurement of the biogenic-substances

Daisuke Kojima, Takashi Takuma, Asuka Inui, Wei Qi, Ryosuke Tsutsumi, Takehiko Yuzuriha, Hiroyasu Kagiyama, Akira Nishiyama, Ichirou Ishimaru

Author Affiliations +

Proceedings Volume 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV; 82290M (2012) https://doi.org/10.1117/12.907892
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

We are aiming at the realization of the non-invasive measurement of the biogenic-substance, such as the blood glucose concentration, by the proposed imaging-type 2-dimensional Fourier spectroscopy. We had successfully obtained the spectroscopic tomography of the mouse's ear with the near-infrared radiation. The proposed Fourier-spectroscopic imaging can limit the measuring depth into the focal plane. So, we can set the focal plane as the measurement plane near the skin surface that is not affected by the optical diffusion of the biological tissues. To analyze the absorption coefficient in the specific wavelength at the vessel area, we can expect to acquire the blood glucose concentration in high accuracy. In the proposed method, we install the variable phase-filter into the optical Fourier transform plane of the imaging optics to give the arbitrary phase-shift to the half flux of objective beams. Because of the imaging optics, only the rays from the focal plane can contribute the formation of the interferogram. Thus, we can obtain the 2-dimensional spectra only on the focal plane. We had successfully obtained the distribution of the spectroscopic-absorption near the skin surface. We are trying to convert the absorptance into the glucose concentration by the quantitative spectroscopic image-processing.

Citation Download Citation

Daisuke Kojima, Takashi Takuma, Asuka Inui, Wei Qi, Ryosuke Tsutsumi, Takehiko Yuzuriha, Hiroyasu Kagiyama, Akira Nishiyama, and Ichirou Ishimaru "Spectroscopic tomography of biological tissues with the near-infrared radiation for the non-invasive measurement of the biogenic-substances", Proc. SPIE 8229, Optical Diagnostics and Sensing XII: Toward Point-of-Care Diagnostics; and Design and Performance Validation of Phantoms Used in Conjunction with Optical Measurement of Tissue IV, 82290M (2 February 2012); https://doi.org/10.1117/12.907892

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available